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| Biological Activity of Kepivance® |
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Kepivance® is a recombinant form of human keratinocyte growth factor
(KGF). The potential mechanisms of Kepivance® during the 5 phases of oral mucositis include1-7:
- Inducing cell proliferation, increasing epithelial thickness, and upregulating cytoprotective mechanisms before myelotoxic therapy.
- Reducing DNA damage.
- Increasing the levels of detoxifying enzymes to protect against
reactive oxygen species (ROS).
- Decreasing levels of pro-inflammatory cytokines.
- Decreasing apoptosis.
As a result, ulceration and pain are reduced.
| 1 |
Jonas CR, Farrell CL, Scully S, et al. Enteral nutrition and keratinocyte growth factor regulate expression of glutathione-related enzyme messenger RNAs in rat intestine. JPEN J Parenter Enteral Nutr. 2000;24:67-75. |
| 2 |
Takeoka M, Ward WF, Pollack H, Kamp DW, Panos RJ. KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol. 1997;272:L1174-L1180. |
| 3 |
Wu KI, Pollack N, Panos RJ, et al. Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure. Am J Physiol. 1998;275:L780-L787. |
| 4 |
Senaldi G, Shaklee CL, Simon B, et al. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro. Hepatology. 1998;27:1584-1591. |
| 5 |
Panoskaltsis-Mortari A, Taylor PA, Rubin JS, et al. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury. Blood. 2000;96:4350-4356. |
| 6 |
Potten CS, Booth D, Cragg NJ, O'Shea JA, Tudor GL, Booth C. Cell kinetic studies in the murine ventral tongue epithelium: the effects of repeated exposure to keratinocyte growth factor. Cell Prolif. 2002;35(suppl 1):22-31. |
| 7 |
Farrell CL, Rex KL, Kaufman SA, et al. Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice. Int J Radiat Biol. 1999;75:609-620. |
ABOUT ORAL MUCOSITIS
ABOUT KEPIVANCE®
TOOLS AND RESOURCES
FOR NURSES
FOR PHARMACISTS
IMPORTANT PRODUCT SAFETY INFORMATION
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